New laboratory participating in the BCMP Summer Scholar Program
The del Mármol Lab
Focus on understanding the olfactory system of mosquitoes and other disease vectors that use their sense of smell to find and bite humans, thereby transmitting deadly diseases like malaria, dengue and yellow fever.
Laboratories* that accepted students in previous years:
*for the complete list of BCMP laboratories, please visit the departmental website
Focus on the human microbiome and how to control the chemistry of human-associated bacteria in order to understand how the microbiome affects human health and disease.
Focus on learning how cell-type and condition-specific patterns of gene expression are established and how they control transcription profiles during development and in response to external signals - to develop treatments for the many diseases where transcription becomes dysregulated.
Focus on the mechanism of gene expression in eukaryotes.
Focus on molecular approaches to gene regulation and protein function during herpes virus replication and latency.
Focus on the chemical biology of protein post-translational modifications (PTMs) in the context of signaling, epigenetics, and cancer - to identify novel therapeutic opportunities for the treatment of cancer and other diseases.
Focus on identifying and characterizing new mechanisms of RNA regulation to explore how RNA regulatory pathways impact stem cell pluripotency, mammalian development, growth, cancer, and neurological diseases - for the development of new therapeutic approaches for cancer and degenerative disease.
Focus on developing and applying single-molecule methods (rather than bulk experiments) to better understand the molecular dynamics of multi-protein complexes that carry out duplication, maintenance and transmission of the genome by observing the individual functional trajectories of proteins.
Walter HHMI Laboratory
Focus on understanding how cells replicate and repair DNA and how these processes go awry in human diseases.
Structural Biology (including our recently launched cryo-EM center):
Hari's work on novel pulse sequences, pulse designs, labeling strategies, and sampling schemes let his group push the boundaries of NMR as a technique, allowing him to tackle larger systems by NMR.
Focus on how other proteins genetically implicated in the Notch pathway modulate signaling in normal and cancer contexts. Priorities include understanding the molecular mechanism of normal and pathogenic activation by ADAM-family metalloproteases, elucidating how Notch cooperates with other factors to control target gene transcription and understanding how negative feedback regulators fine-tune signaling.
Focus on the biochemical and biophysical methods (including X-ray crystallography and cryo electron microscopy) to distill problems of central importance in cancer biology to their structural and mechanistic essentials; especially interested in the structure and regulation of kinases and their mutational activation in cancer, and in using structural approaches to facilitate development of anti-cancer drugs.
Focus on the mechanistic principles that govern signaling through the ubiquitin proteasome system - to propose and test new avenues of therapeutic intervention, such as targeted protein degradation or SPLiNTs. The group has contributed to the now widespread application of targeted protein degradation in drug development and as a powerful tool to study biology.
James Chou Laboratory
Focus on the molecular mechanism of membrane channels, receptors, and transporters.
Focus on G protein-coupled receptors (GPCRs) and non-canonical signal transduction pathways.
Focus on receptor-ligand interactions and transmembrane signal transmission that are relevant to immunology, hemostasis, and human disease using structural, cell biological, and single molecule techniques. A unifying theme is how force interacts with protein conformational change to activate integrins, von Willebrand factor, transforming growth factor-beta family proteins, and adhesins on malaria sporozoites.
Focus on elucidating the molecular mechanism of signal transduction by immune receptors, especially innate immune receptors.
Focus on first-in-class inhibitors and prototype drugs against deubiquitinating enzymes.
Other groups with potential openings:
Kevin Struhl, Gerhard Wagner, Sun Hur, and other BCMP faculty
Genomics - The Cohort Study Project at Boston Children's Hospital has multiple openings for students that are interested in working with investigators on sequencing and data analysis projects in a variety of disease areas including neurological, endocrine, psychiatric, gastric and more.
Graduate Programs affiliated with Harvard Medical School: